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KMID : 0939920090410030145
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대한암학회지
2009 Volume.41 No. 3 p.145 ~ p.154
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Apoptosis and Expression of AQP5 and TGF-? in the Irradiated Rat Submandibular Gland
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Choi Jin-Hwa
Wu Hong-Gyun
Chung Kyung-Chun
Lee Seung-Hee
Kwon Eun-Kyung
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Abstract
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Purpose: To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-?(TGF-?) in the rat submandibular gland (SMG).
Materials and Methods: SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-?was determined by immunohistochemical staining.
Results: At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-?expression by ductal cells were evident.
Conclusion: Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-?expression in different SMG cell types.
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KEYWORD
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Submandibular gland, Radiation, Apoptosis, AQP5, TGF-?
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